AMC CRITICAL - Urgent Detection of Bloodstream Infections

Description

Critical Microbiological Liquid Biopsy (MLB)

AMC CRITICAL is an advanced clinical analysis designed to detect bacterial and other microorganism infections present in venous blood in critical situations. It uses third-generation sequencing (NGS) techniques to comprehensively identify all microorganisms and resistance plasmids present.

Critical Situations

Urgent analysis for cases requiring immediate diagnosis and timely treatment.

• Sepsis and septic shock
• Transplant infections
• Hard-to-detect infections
• Critical hospital cases

Advanced Technology

Third-generation sequencing with artificial intelligence algorithms.

• 3rd-generation NGS
• Sensitivity >99.55%
• Minimum depth 30X
• No PCR amplification
• AI algorithms

Detection Capabilities

Microorganisms Detected

• More than 1,700,000 microorganisms
• Pathogenic and opportunistic bacteria
• Viruses and fungi
• Mycobacteria
• Parasites
• Species-level identification

Antimicrobial Resistance

• Resistance plasmids
• Antibiotic resistance genes
• Multidrug resistance (MDR)
• Extreme resistance (XDR)
• Resistance mechanisms
• Susceptibility profiles

Technology

Third-Generation NGS Technology

AMC CRITICAL uses the most advanced third-generation sequencing technology, providing ultra-fast results with maximum diagnostic precision.

Technical Specifications

Quality Parameters

• ✅ Sensitivity: >99.55%
• ✅ Specificity: >99.55%
• ✅ Depth: Minimum 30X
• ✅ Read length: >4 Mb
• ✅ Analysis time: 1-2 days

Technological Advantages

• ✅ No PCR: Avoids biases and artifacts
• ✅ Easy reassembly: Complete genomes
• ✅ Lower error: High fidelity
• ✅ Integrated AI: Intelligent analysis
• ✅ Broad coverage: 1.7M microorganisms

Ultra-fast

Results in 1-2 days vs 3-7 days for traditional culture

Ultra-sensitive

Detects pathogens undetectable by culture

Integrated AI

Intelligent data analysis algorithms

Sample

Sample Specifications

Critical Sample

For urgent analyses, the quality and correct handling of the sample is essential to obtain accurate results in record time.

Sample Type

• Venous blood - Primary sample
• Volume: 5-10 mL
• Tube: EDTA or heparin
• Temperature: Room temperature
• Transport: Immediate preferable

Critical Timings

• Processing: Immediate
• Stability: 24h at 4°C
• Analysis: 1-2 days
• Reporting: 24-48 hours
• Emergencies: Check availability

Special Instructions

• Draw the sample before starting antibiotics when possible
• In critical cases, do not delay treatment for sample collection
• Communicate urgency to the laboratory when sending the sample
• Provide relevant clinical information

Results

Interpretation of Results

The AMC CRITICAL report provides critical information for urgent clinical decision-making, including complete microbial identification and resistance profile.

Information Included

• Microorganisms detected
• Relative abundance
• Species-level identification
• Resistance plasmids
• Resistance genes
• Therapeutic recommendations

Critical Alerts

• Multidrug-resistant pathogens
• Critical microorganisms
• Emerging resistances
• Therapeutic incompatibilities
• Urgent recommendations
• Direct contact if needed

Communication of Critical Results

For critical cases, we establish direct communication with the responsible physician:

• Immediate telephone notification of critical findings
• Preliminary report within 24 hours
• Complete report within 48 hours
• Guidance in interpreting results
• Follow-up of complex cases

Clinical indications

Critical Clinical Indications

AMC CRITICAL is specifically indicated for clinical situations that require urgent and accurate microbiological diagnosis.

Sepsis and Septic Shock

• Sepsis of unknown origin
• Septic shock
• Primary bacteremia
• Systemic inflammatory response syndrome
• Multiorgan failure of infectious origin
• Cases with negative blood cultures

Transplants

• Pre-transplant screening (donor)
• Pre-transplant screening (recipient)
• Post-transplant infections
• Rejection vs infection
• Immunosuppression and opportunistic infections
• Post-transplant follow-up

Hard-to-Detect Infections

• Persistent negative blood cultures
• Infections by fastidious microorganisms
• Intracellular pathogens
• Complex polymicrobial infections
• Non-culturable microorganisms
• Cases with prior antibiotics

Other Critical Cases

• Immunocompromised patients
• Serious nosocomial infections
• Febrile neutropenia
• Infective endocarditis
• Meningitis/encephalitis
• ICU infections

Advantages in Critical Situations

• Speed: Results in 1-2 days vs 3-7 days
• Sensitivity: Higher than traditional cultures
• Breadth: >1,700,000 microorganisms
• Resistances: Direct detection of genes
• Precision: Species-level identification
• Support: 24/7 clinical guidance